Publications

Suppressing Anaphase-Promoting Complex/Cyclosome –Cell Division Cycle 20 Activity to Enhance the Effectiveness of Anti-Cancer Drugs That Induce Multipolar Mitotic Spindles.

Scott C. Schuyler#, Hsin-Yu Chen and Kai-Ping Chang#. (2024)

Int. J. Mol. Sci. 2024, 25(12), 6329

#corresponding author

Editorial: Chromosome bi-orientation, tension and the spindle-assembly checkpoint.

Scott C. Schuyler#. (2023)

Front. Cell Dev. Biol. 2023 Jul. Volume 11

#corresponding author

Podocalyxin-Like Protein 1 Regulates Pluripotency through the Cholesterol Biosynthesis Pathway.

Chen WJ, Huang WK, Pather SR, Chang WF, Sung LY, Wu HC, Liao MY, Lee CC, Wu HH, Wu CY, Liao KS, Lin CY, Yang SC, Lin H, Lai PL, Ng CH, Hu CM, Chen IC, Chuang CH, Lai CY, Lin PY, Lee YC, Schuyler SC, Schambach A, Lu FL, Lu J. (2022)

Adv Sci (Weinh). Nov 14:e2205451.

Development of a Chemical Cocktail That Rescues Mouse Brain Demyelination in a Cuprizone-Induced Model.

Pei-Lun Lai, Chi-Hou Ng, Chia-Hsin Wu, Chien-Ying Lai, Scott C. Schuyler, Vicki Wang, Hsuan Lin, Yueh-Chang Lee, Ming-Hsi Chuang, Chang-Huan Yang, Wei-Ju Chen, Hsiao-Chun Huang, and Jean Lu. (2022)

Cells. 2022 Mar 24; 11(7):1091

Comparative Analyses of Single-Cell Transcriptomic Profiles between In Vitro Totipotent Blastomere-like Cells and In Vivo Early Mouse Embryonic Cells.

Po-Yu Lin, Denny Yang, Chi-Hsuan Chuang, Hsuan Lin, Wei-Ju Chen, Chia-Ying Chen, Trees-Juen Chuang, Chien-Ying Lai, Long-Yuan Li, Scott C Schuyler, Frank Leigh Lu, Yu-Chuan Liu, Jean Lu. (2021)

Cells. 2021 Nov.10;10(11): 3111

Using budding yeast to identify molecules that block cancer cell 'mitotic slippage' only in the presence of mitotic poisons.

Scott C. Schuyler# and Hsin-Yu Chen. (2021)

Int. J. Mol. Sci. 2021 Jul. 22(15), 7985

#corresponding author

Protein Complexes Form a Basis for Complex Hybrid Incompatibility.

Krishna B. S. Swamy , Scott C. Schuyler and Jun-Yi Leu. (2021) Front. Genet. 2021 Feb 09; 12: 609766.

Deletion of Budding Yeast MAD2 Suppresses Clone-to-Clone Diferences in Artificial Linear Chromosome Copy Numbers and Gives Rise to Higher Retention Rates.

Scott C. Schuyler#, Lin-Ing Wang, Yi-Shan Ding*, Yi-Chieh Lee, and Hsin-Yu Chen. (2020)

Microorganisms. 2020 Sep 29;8(10):E1495

*equal contribution, #corresponding author

Combination Vaccination With Tetanus Toxoid and Enhanced Tumor-Cell Based Vaccine Against Cervical Cancer in a Mouse Model.

Donia Alson, Scott C Schuyler, Bo-Xin Yan, Karthika Samimuthu, Jiantai Timothy Qiu. (2020)

Front Immunol. 2020 May;11:927.

Down-regulation of ATF1 leads to early neuroectoderm differentiation of human embryonic stem cells by increasing the expression level of SOX2.

Yang SC, Liu JJ, Wang CK, Lin YT, Tsai SY, Chen WJ, Huang WK, Tu PA, Lin YC, Chang CF, Cheng CL, Lin H, Lai CY, Lin CY, Lee YH, Chiu YC, Hsu CC, Hsu SC, Hsiao M, Schuyler SC, Lu FL, Lu. J. (2019)

FASEB J. 2019 Sep;33(9):10577-10592.

Effect of Multiple Vaccinations with Tumor Cell-Based Vaccine with Codon-Modified GM-CSF on Tumor Growth in a Mouse Model. Cancers.

Jiantai Timothy Qiu#, Donia Alson, Ta-Hsien Lee, Ching-Chou Tsai, Ting-We Yu, Yu-Sing Chen, Ya-Fang Cheng, Chu-Chi Lin, Scott Schuyler# (2019)

Cancers. 2019 Mar 15;11(3):368

*equal contribution, #co-corresponding authors

Peptide inhibitors of the anaphase promoting-complex that cause sensitivity to microtubule poison.

Scott C. Schuyler, Yueh-Fu Olivia Wu, Hsin-Yu Chen*, Yi-Shan Ding, Chia-Jung Lin, Yu-Ting Chu, Ting-Chun Chen, Louis Liao, Wei-Wei Tsai, Anna Huang, Lin-Ing Wang, Ting-Wei Liao , Jia-Hua Jhuo, Vivien Cheng. (2018)

PLoS ONE. 2018 Jun 8;13(6):e0198930

*equal contribution

The anaphase-promoting complex works together with the SCF complex for proteolysis of the S-phase cyclin Clb6 during the transition from G1 to S phase.

Shiao-Yii Wu*, Vivian Jen-Wei Kuan*, Yao-Wei Tseng*, Scott C. Schuyler#, and Yue-Li Juang#. (2016)

Fungal Genet Biol. 2016 Mar 16; 91:6-19.

*equal contribution, #co-corresponding authors

Akt suppresses DLK for maintaining self-renewal of mouse embryonic stem cells.

Wu CC, Wu HJ, Wang CH, Lin CH, Hsu SC, Chen YR, Hsiao M, Schuyler SC, Lu FL, Ma N, Lu J. (2015)

Cell Cycle. 2015 Apr 15; 14(8):1207-17.

The Hsp90-dependent proteome is conserved and enriched for hub proteins with high levels of protein-protein connectivity.

Gopinath RK*, You ST*, Chien KY*, Swamy KBS, Yu JS, Schuyler SC# and Leu JY#. (2014)

Genome Biol Evol. 2014 Oct 13;6(10):2851-65.

*equal contribution, #co-corresponding authors

Functional Impact of RNA Editing and ADARs on Regulation of Gene Expression: Perspectives from Deep Sequencing Studies.

Hsuan L, Ma C-P, Chen Y-T, Schuyler SC, Chang K-P and Tan BC. (2014)

Cell & Bioscience. 2014 Aug 19;4:44

CCL5/RANTES is important for inducing osteogenesis of human mesenchymal stem cells and is regulated by dexamethasone.

Liu YC, Kao YT, Huang WK, Lin KY, Wu SC, Hsu SC, Schuyler SC, Li LY, Leigh Lu F, Lu J. (2014)

Biosci Trends. 2014 Jun;8(3):138-43.

miR-200c and GATA binding protein 4 regulate human embryonic stem cell renewal and differentiation.

Huang H-N, Chen S-Y, Hwang S-M, Su M-W, Mai W, Wang H-W, Cheng W-C, Schuyler SC, Ma N, Lu FL, Lu J. (2014)

Stem Cell Res. 2014 Mar;12(2):338-353.

Array-Based High-Throughput Screening in Mouse Embryonic Stem Cells with shRNAs.

Wang, C.-H., Ma, N., Lin, Y.-T., Wu, C.-C., Wu, H.-J., Yu, C.-C., Hsiao, M., Lu, F. L., Schuyler SC. and Lu, J. (2013)

Current Protocols in Stem Cell Biology. 2013 Sep 20;26:5C.3.1–5C.3.19.

Sonic hedgehog antagonists induce cell death in acute myeloid leukemia cells in the presence of lipopolysaccharides, tumor necrosis factor-α, or interferons.

Lu FL, Yu C-C, Chiu H-H, Liu HE, Chen S-Y, Lin S, Goh T-Y, Hsu H-C, Chien C-H, Wu H-C, Chen M-S, Schuyler SC, Hsieh W-S, Wu M-H, Lu J. (2013)

Invest. New Drug. 2013 Aug; 31(4):823-32

The Mad1-Mad2 balancing act - a damaged spindle checkpoint in chromosome instability and cancer.

Schuyler SC, Wu Y-F*, Kuan VJ-W*. (2012)

J Cell Sci. 2012 Sep 15;125(Pt 18):4197-4206

*equal contribution

Functions of the mitotic B-type cyclins CLB1, CLB2, and CLB3 at mitotic exit antagonized by the CDC14 phosphatase.

Tzeng Y-W, Huang JN, Schuyler SC, Wu C-H, Juang Y-L. (2011)

Fungal Genet Biol. 2011 Oct;48(10):966-78.

Reduced Mad2 expression keeps relaxed kinetochores from arresting budding yeast in mitosis.

Barnhart EL, Dorer RK, Murray AW, Schuyler SC. (2011)

Mol Biol Cell. 2011 Jul;22(14):2448-2457.

Japanese encephalitis virus co-opts the ER-stress response protein GRP78 for viral infectivity.

Wu YP, Chang CM, Hung CY, Tsai MC, Schuyler SC, Wang RYL. (2011)

Virol J. 8:128. Erratum in: Virol J. 8:338.

An in vitro assay for Cdc20-dependent mitotic anaphase-promoting complex activity from budding yeast.

Schuyler SC, Murray AW. (2009)

Methods Mol Biol. 545:271-85

The differential roles of budding yeast Tem1p, Cdc15p, and Bub2p protein dynamics in mitotic exit.

Molk JN, Schuyler SC, Liu JY, Evans JG, Salmon ED, Pellman D, Bloom K. (2004)

Mol Biol Cell. Apr;15(4):1519-32

The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix.

Schuyler SC, Liu JY, Pellman D. (2003)

J Cell Biol. Feb 17;160(4):517-28

Analysis of the size and shape of protein complexes from yeast.

Schuyler SC, Pellman D. (2002)

Methods Enzymol. 351:150-68

Microtubule "plus-end-tracking proteins": The end is just the beginning.

Schuyler SC, Pellman D. (2001)

Cell. May 18;105(4):421-4

Search, capture and signal: games microtubules and centrosomes play.

Schuyler SC, Pellman D. (2001)

J Cell Sci. Jan;114(Pt 2):247-55

Positioning of the mitotic spindle by a cortical-microtubule capture mechanism.

Lee L, Tirnauer JS, Li J, Schuyler SC, Liu JY, Pellman D. (2000)

Science. Mar 24;287(5461):2260-2

The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain.

Berrueta L, Tirnauer JS, Schuyler SC, Pellman D, Bierer BE. (1999)

Curr Biol. Apr 22;9(8):425-8

The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules.

Berrueta L, Kraeft SK, Tirnauer JS, Schuyler SC, Chen LB, Hill DE, Pellman D, Bierer BE. (1998)

Proc Natl Acad Sci U S A. Sep 1;95(18):10596-601

Dynamic simulations of the molecular conformations of wild type and mutant xanthan polymers suggest that conformational differences may contribute to observed differences in viscosity.

Levy S, Schuyler SC, Maglothin RK, Staehelin LA. (1996)

Biopolymers. Feb;38(2):251-72

﻿Scott C. Schuyler(曲桐)

Department of Biomedical Sciences

Publications

Suppressing Anaphase-Promoting Complex/Cyclosome –Cell Division Cycle 20 Activity to Enhance the Effectiveness of Anti-Cancer Drugs That Induce Multipolar Mitotic Spindles.​

Scott C. Schuyler#, Hsin-Yu Chen and Kai-Ping Chang#. (2024)

Int. J. Mol. Sci. 2024, 25(12), 6329

#corresponding author

​

Editorial: Chromosome bi-orientation, tension and the spindle-assembly checkpoint. ​

Scott C. Schuyler#. (2023)

Front. Cell Dev. Biol. 2023 Jul. Volume 11

#corresponding author

​

Podocalyxin-Like Protein 1 Regulates Pluripotency through the Cholesterol Biosynthesis Pathway. ​

Chen WJ, Huang WK, Pather SR, Chang WF, Sung LY, Wu HC, Liao MY, Lee CC, Wu HH, Wu CY, Liao KS, Lin CY, Yang SC, Lin H, Lai PL, Ng CH, Hu CM, Chen IC, Chuang CH, Lai CY, Lin PY, Lee YC, Schuyler SC, Schambach A, Lu FL, Lu J. (2022)

Adv Sci (Weinh). Nov 14:e2205451.

​

Development of a Chemical Cocktail That Rescues Mouse Brain Demyelination in a Cuprizone-Induced Model. ​

Pei-Lun Lai, Chi-Hou Ng, Chia-Hsin Wu, Chien-Ying Lai, Scott C. Schuyler, Vicki Wang, Hsuan Lin, Yueh-Chang Lee, Ming-Hsi Chuang, Chang-Huan Yang, Wei-Ju Chen, Hsiao-Chun Huang, and Jean Lu. (2022)

Cells. 2022 Mar 24; 11(7):1091

​

Comparative Analyses of Single-Cell Transcriptomic Profiles between In Vitro Totipotent Blastomere-like Cells and In Vivo Early Mouse Embryonic Cells. ​

Po-Yu Lin, Denny Yang, Chi-Hsuan Chuang, Hsuan Lin, Wei-Ju Chen, Chia-Ying Chen, Trees-Juen Chuang, Chien-Ying Lai, Long-Yuan Li, Scott C Schuyler, Frank Leigh Lu, Yu-Chuan Liu, Jean Lu. (2021)

Cells. 2021 Nov.10;10(11): 3111

Using budding yeast to identify molecules that block cancer cell 'mitotic slippage' only in the presence of mitotic poisons.

Scott C. Schuyler# and Hsin-Yu Chen. (2021)

Int. J. Mol. Sci. 2021 Jul. 22(15), 7985

#corresponding author

Protein Complexes Form a Basis for Complex Hybrid Incompatibility.

Krishna B. S. Swamy , Scott C. Schuyler and Jun-Yi Leu. (2021) Front. Genet. 2021 Feb 09; 12: 609766.

​

Deletion of Budding Yeast MAD2 Suppresses Clone-to-Clone Diferences in Artificial Linear Chromosome Copy Numbers and Gives Rise to Higher Retention Rates.

Scott C. Schuyler#*, Lin-Ing Wang*, Yi-Shan Ding*, Yi-Chieh Lee, and Hsin-Yu Chen. (2020)

Microorganisms. 2020 Sep 29;8(10):E1495

*equal contribution, #corresponding author

​

Combination Vaccination With Tetanus Toxoid and Enhanced Tumor-Cell Based Vaccine Against Cervical Cancer in a Mouse Model.

Donia Alson, Scott C Schuyler, Bo-Xin Yan, Karthika Samimuthu, Jiantai Timothy Qiu. (2020)

Front Immunol. 2020 May;11:927.

​

Down-regulation of ATF1 leads to early neuroectoderm differentiation of human embryonic stem cells by increasing the expression level of SOX2.

Yang SC, Liu JJ, Wang CK, Lin YT, Tsai SY, Chen WJ, Huang WK, Tu PA, Lin YC, Chang CF, Cheng CL, Lin H, Lai CY, Lin CY, Lee YH, Chiu YC, Hsu CC, Hsu SC, Hsiao M, Schuyler SC, Lu FL, Lu. J. (2019)

FASEB J. 2019 Sep;33(9):10577-10592.

​

Effect of Multiple Vaccinations with Tumor Cell-Based Vaccine with Codon-Modified GM-CSF on Tumor Growth in a Mouse Model. Cancers.

Jiantai Timothy Qiu#*, Donia Alson*, Ta-Hsien Lee, Ching-Chou Tsai, Ting-We Yu, Yu-Sing Chen, Ya-Fang Cheng, Chu-Chi Lin, Scott Schuyler# (2019)

Cancers. 2019 Mar 15;11(3):368

*equal contribution, #co-corresponding authors

​

Peptide inhibitors of the anaphase promoting-complex that cause sensitivity to microtubule poison.

Scott C. Schuyler*, Yueh-Fu Olivia Wu*, Hsin-Yu Chen*, Yi-Shan Ding, Chia-Jung Lin, Yu-Ting Chu, Ting-Chun Chen, Louis Liao, Wei-Wei Tsai, Anna Huang, Lin-Ing Wang, Ting-Wei Liao , Jia-Hua Jhuo, Vivien Cheng. (2018)

PLoS ONE. 2018 Jun 8;13(6):e0198930

*equal contribution

​

The anaphase-promoting complex works together with the SCF complex for proteolysis of the S-phase cyclin Clb6 during the transition from G1 to S phase.

Akt suppresses DLK for maintaining self-renewal of mouse embryonic stem cells.

The Hsp90-dependent proteome is conserved and enriched for hub proteins with high levels of protein-protein connectivity.

Functional Impact of RNA Editing and ADARs on Regulation of Gene Expression: Perspectives from Deep Sequencing Studies.

​

CCL5/RANTES is important for inducing osteogenesis of human mesenchymal stem cells and is regulated by dexamethasone.

miR-200c and GATA binding protein 4 regulate human embryonic stem cell renewal and differentiation.

Array-Based High-Throughput Screening in Mouse Embryonic Stem Cells with shRNAs.

Sonic hedgehog antagonists induce cell death in acute myeloid leukemia cells in the presence of lipopolysaccharides, tumor necrosis factor-α, or interferons.

The Mad1-Mad2 balancing act - a damaged spindle checkpoint in chromosome instability and cancer.

Functions of the mitotic B-type cyclins CLB1, CLB2, and CLB3 at mitotic exit antagonized by the CDC14 phosphatase.

Reduced Mad2 expression keeps relaxed kinetochores from arresting budding yeast in mitosis.

Japanese encephalitis virus co-opts the ER-stress response protein GRP78 for viral infectivity.

An in vitro assay for Cdc20-dependent mitotic anaphase-promoting complex activity from budding yeast.

The differential roles of budding yeast Tem1p, Cdc15p, and Bub2p protein dynamics in mitotic exit.

The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix.

Analysis of the size and shape of protein complexes from yeast.

Microtubule "plus-end-tracking proteins": The end is just the beginning.

Search, capture and signal: games microtubules and centrosomes play.

Positioning of the mitotic spindle by a cortical-microtubule capture mechanism.

The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain.

The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules.

Dynamic simulations of the molecular conformations of wild type and mutant xanthan polymers suggest that conformational differences may contribute to observed differences in viscosity.

Scott C. Schuyler(曲桐)

Suppressing Anaphase-Promoting Complex/Cyclosome –Cell Division Cycle 20 Activity to Enhance the Effectiveness of Anti-Cancer Drugs That Induce Multipolar Mitotic Spindles.

Editorial: Chromosome bi-orientation, tension and the spindle-assembly checkpoint.

Podocalyxin-Like Protein 1 Regulates Pluripotency through the Cholesterol Biosynthesis Pathway.

Development of a Chemical Cocktail That Rescues Mouse Brain Demyelination in a Cuprizone-Induced Model.

Comparative Analyses of Single-Cell Transcriptomic Profiles between In Vitro Totipotent Blastomere-like Cells and In Vivo Early Mouse Embryonic Cells.

Scott C. Schuyler#, Lin-Ing Wang, Yi-Shan Ding*, Yi-Chieh Lee, and Hsin-Yu Chen. (2020)

Jiantai Timothy Qiu#, Donia Alson, Ta-Hsien Lee, Ching-Chou Tsai, Ting-We Yu, Yu-Sing Chen, Ya-Fang Cheng, Chu-Chi Lin, Scott Schuyler# (2019)

Scott C. Schuyler, Yueh-Fu Olivia Wu, Hsin-Yu Chen*, Yi-Shan Ding, Chia-Jung Lin, Yu-Ting Chu, Ting-Chun Chen, Louis Liao, Wei-Wei Tsai, Anna Huang, Lin-Ing Wang, Ting-Wei Liao , Jia-Hua Jhuo, Vivien Cheng. (2018)